Effect of Pre-Hospital ARNI Therapy on Short-Term Outcomes in HFrEF

Future University in Egypt

Status: Enrolling

Conditions: Heart Failure

Treatments: Other: No prehospital ARNI use; Other: Prehospital ARNI use

Study type: Observational

Funder types: Other

Identifiers

NCT07347925

REC-FPFUE-NO3/2025

Details and patient eligibility

About

This study looks at people with heart failure who are admitted to the hospital. The goal of the study is to understand whether taking a heart failure medicine called angiotensin receptor-neprilysin inhibitor (ARNI) before hospital admission affects short-term health outcomes.

The study will compare two groups of participants: those who were already taking ARNI before coming to the hospital and those who were not. Information will be collected from medical records during the hospital stay, including heart-related events, kidney-related events, and how long participants stay in the hospital.

Some participants will also be followed for a short period after discharge. This study may help improve understanding of outcomes associated with ARNI use in people with heart failure in routine clinical care.

Enrollment: 140 estimated patients

Sex: All

Ages: 18+ years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• >= 18 years, male or female EF <40%

Exclusion criteria

• EF>40% Pregnancy or breastfeeding

Trial design

140 participants in 2 patient groups

Prehospital ARNI users

Treatment:

Other: Prehospital ARNI use

Non-Prehospital ARNI users

Treatment:

Other: No prehospital ARNI use