Effect of Pre-operative Depo Medroxyprogesterone Acetate on Serum Anti-mullerian Hormone Level After Laparoscopic Ovarian Cystectomy of Endometriomas

Mahidol University

Status and phase: Completed; Phase 2; Phase 1

Conditions: Endometriosis

Treatments: Drug: depot medroxyprogesterone acetate

Study type: Interventional

Funder types: Other

Identifiers

NCT01791413

02-55-13

Details and patient eligibility

About

The purpose of this study is to evaluate the ovarian reserve changes after preoperative depot medroxyprogesterone acetate (DMPA) in women with ovarian endometrioma undergoing laparoscopic cystectomy.

Enrollment: 40 patients

Sex: Female

Ages: 18 to 40 years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• Healthy women 18-40 years old
• A diagnosis of endometrioma with diameter of at least 3 cm.
• Candidates for laparoscopic cystectomy

Exclusion criteria

• Patients' refusal to participate
• Not candidate for depot medroxyprogesterone acetate such as: cirrhosis, chronic kidney disease, venous thrombosis
• Use of estrogen-suppressive drugs in the preceding 3 months, such as:

Oral contraceptives, GnRH analogues, Progestins, Danazol

• Pathology report present no endometriosis

Trial design

Primary purpose: Treatment

Allocation: Randomized

Interventional model: Parallel Assignment

Masking: None (Open label)

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40 participants in 2 patient groups

depot medroxyprogesterone acetate

Active Comparator group

Treatment:

Drug: depot medroxyprogesterone acetate

No depot medroxyprogesterone acetate

No Intervention group