Effect of Prebiotics on Intestinal Gas Production, Microbiota and Digestive Symptoms

Vall d'Hebron University Hospital (HUVH)

Status: Completed

Conditions: Healthy

Treatments: Dietary Supplement: Bimuno Galacto-oligo-saccharide

Study type: Interventional

Funder types: Other

Identifiers

NCT02618239

PR(AG)296/2013

Details and patient eligibility

About

Non-absorbable, fermentable residues in the diet increase intestinal gas production and induce gas-related symptoms, such as flatulence, abdominal bloating and distention; however, prebiotics, which are also fermented by colonic bacteria have been shown to improve this type of symptoms. The aim is to demonstrate changes in metabolic activity of gut microbiota and colonic biomass induced by prebiotics.

Healthy subjects (n=20) will be administered a prebiotic (Galacto-oligo-saccharide; 2.8 g/d) for 3 weeks; they will also receive a standard diet during three days. The following outcomes will be measured immediately before, at the beginning and at the end of the treatment: a) number of gas evacuations during daytime for 2 days on the standard diet, by means of an event marker; b) volume of gas evacuated via a rectal tube during 4 hours after a test meal, by means of a barostat; c) microbiota composition by fecal analysis.

Enrollment: 20 patients

Sex: All

Ages: 18 to 80 years old

Volunteers: Accepts Healthy Volunteers

Inclusion criteria

Exclusion criteria

• gastrointestinal symptoms
• recent (3 months) antibiotic intake
• recent (3 months) change of diet
• recent (3 months) gastroenteritis

Trial design

Primary purpose: Basic Science

Allocation: N/A

Interventional model: Single Group Assignment

Masking: None (Open label)

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20 participants in 1 patient group

Healthy subjects

Experimental group

Description:

Bimuno Galacto-oligo-saccharide administration 2.7 g/d x 3 weeks

Treatment:

Dietary Supplement: Bimuno Galacto-oligo-saccharide