Effect of Pregabalin or Adductor Canal Block on Postoperative Analgesia

Ankara Diskapi Training and Research Hospital

Status: Completed

Conditions: Postoperative Pain After Knee Arthroscopy

Treatments: Drug: adductor canal block including bupivacaine; Drug: pregabalin (lyrica); Drug: Placebo oral tablet

Study type: Interventional

Funder types: Other

Identifiers

NCT03530280

pregabalin

Details and patient eligibility

About

arthroscopically Anterior Cruciate Ligament Reconstruction (ACL) under spinal anesthesia were included in this study.

Full description

Patients who American Society of Anesthesiologists (ASA) classification I to II scheduled to undergo arthroscopically assisted ACL reconstructions under spinal anesthesia are included in this study. The first group is administered 150 mg oral pregabalin 1 hour before surgery and the postoperative sham block was performed with an ultrasound probe. The second group is the control group; patients in this group are administered a placebo capsule 1 hour before surgery and sham block was performed with an ultrasound probe.The third group is administered a placebo capsule 1 hour before surgery and postoperative adductor canal block is performed. All patients will be received postoperative a tramadol i.v. patient control analgesia device. At the end of 24 hours, the total amount of tramadol consumed by the patient will be recorded from the patient control analgesia. NRS score, white fast track, satisfaction will be questioned.

Enrollment: 51 patients

Sex: All

Ages: 18 to 70 years old

Volunteers: Accepts Healthy Volunteers

Inclusion criteria

• Patients between the ages of 18 and 70 years
• American Society of Anesthesiologists I or II
• Scheduled to undergo knee arthroscopy

Exclusion criteria

• allergic to any medicines
• History of drug or alcohol abuse,
• Opioids or sedative medications
• History of psychiatric conditions
• Pregnant or lactating women

Trial design

Primary purpose: Other

Allocation: Randomized

Interventional model: Parallel Assignment

Masking: Single Blind

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51 participants in 3 patient groups, including a placebo group

pregabalin (lyrica)

Active Comparator group

Description:

pregabalin (lyrica) 150 mg preoperative 1 hour before and the postoperative sham block will perform.

Treatment:

Drug: pregabalin (lyrica)

placebo group

Placebo Comparator group

Description:

a placebo capsule 1 hour before surgery and the postoperative sham block will perform.

Treatment:

Drug: Placebo oral tablet

adductor channel block group

Active Comparator group

Description:

A preoperative placebo capsule will be given.This group will receive postoperative adductor channel block including 10 mL of 0.25% bupivacaine with 5 μg/mL epinephrine

Treatment:

Drug: adductor canal block including bupivacaine