Effect of Preoperative Diclofenac Potassium on Postoperative Endodontic Pain

Cairo University (CU)

Status and phase

Completed

Phase 3

Phase 2

Conditions

Pulpitis - Irreversible

Treatments

Drug: Diclofenac Potassium 50mg Tab.

Drug: Placebo

Study type

Interventional

Funder types

Other

Identifiers

NCT03341260

CEBC-CU-2016-11-167

Details and patient eligibility

About

The purpose of this study is to assess the effect of preoperative a single-dose of 50 mg diclofenac potassium on postoperative endodontic pain in mandibular molars with symptomatic irreversible pulpitis.

Full description

Patients with moderate-to-severe preoperative pain are selected. Patients receive either a single-dose of 50 mg diclofenac potassium (group A) or a placebo tablet as a control (group B). All patients receive the assigned premedication one hour before single-visit root canal treatment. Postoperative endodontic pain is measured at the following time points: 6 , 12,24,48 h after treatment. The incidence of analgesic intake is also recorded.

Enrollment

70 patients

Sex

All

Ages

18 to 60 years old

Volunteers

No Healthy Volunteers

Inclusion criteria

Patients with active pain (moderate-to-severe) in mandibular molars.
Patients with prolonged response to cold testing and electric pulp tester.
Patient with the ability to understand and use pain scales.
Patient with vital coronal pulp tissue on access.
Patient who accept to enroll to the study.

Exclusion criteria

Patients' allergies or any other contraindication to diclofenac potassium or articaine.
Pregnant and lactating females.
Patients having pain medication in the last 6 hours.
Patient has more than one symptomatic mandibular tooth in the same quadrant.
Patients with periradicular pathosis and/or radiolucency other than widened periodontal ligaments.
Patients with active peptic ulcer and gastrointestinal disorders.
Patients with history of bleeding problems or anticoagulant use within the last month.