Effect of Preoperative Oral Carbohydrate on Hypotension After Anesthesia Induction in Elderly Patients With Joint Replacement

Zhejiang University

Status: Not yet enrolling

Conditions: Post-induction Hypotension; Carbohydrates; Aged

Treatments: Dietary Supplement: Carbohydrate

Study type: Interventional

Funder types: Other

Identifiers

NCT05749328

2022-0949

Details and patient eligibility

About

The goal of this Randomized controlled trial is to investigate the effect of shortening the duration of preoperative oral carbohydrate drinks on blood pressure after anesthesia induction in elderly patients undergoing joint replacement surgery. The main question it aims to answer is Whether preoperative oral carbohydrate drinks can reduce the incidence of hypotension after anesthesia-induced hypotension in elderly patients undergoing joint replacement surgery.According to the numerical table method, the patients in the experimental group will drink carbohydrate drinks the night before the operation and 3 hours before the operation, and the control group patients will routinely fast

Enrollment: 210 estimated patients

Sex: All

Ages: 65 to 80 years old

Volunteers: No Healthy Volunteers

Inclusion criteria

1. Patients undergoing elective unilateral joint replacement (total hip or knee)
2. ASAⅠ-Ⅲ

Exclusion criteria

1. Diagnosed patients at high risk of reflux aspiration (diabetes mellitus, obesity (BMI>30), gastrointestinal obstruction, elevated intracranial pressure, and esophageal disease)
2. Eating disorders
3. History of gastrointestinal or epigastric surgery
4. Recent use of drugs that affect gastrointestinal motility
5. Heart disease (severe arrhythmias, severe heart valve disease, heart failure, unstable angina on the day of surgery)
6. Severe poorly controlled hypertension (MAP≥135 mmHg) or hypotension (MAP≤55 mmHg) before induction
7. Difficult airway
8. Severe hepatic and renal insufficiency

Trial design

Primary purpose: Prevention

Allocation: Randomized

Interventional model: Parallel Assignment

Masking: Quadruple Blind

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210 participants in 2 patient groups

Carbohydrate group

Experimental group

Description:

Fasting at 20:00 on the eve of surgery, give 800ml of carbohydrate drink, the patient drinks freely, no more than 200ml per hour, to 3h before surgery, give carbohydrate drink again, according to 5ml/kg calculated dose, maximum 400ml, drink within 30 minutes.

Treatment:

Dietary Supplement: Carbohydrate

Contral group

No Intervention group

Description:

Fasting at 20:00 on the eve of surgery, fasting at 24:00, until the induction of anesthesia on the day of surgery