Effect of Preoperative Pregabalin on Propofol Induction Dose

Université de Sherbrooke

Status and phase: Completed; Phase 4

Conditions: Laparoscopic Surgery; Anesthesia, General

Treatments: Drug: Pregabalin

Study type: Interventional

Funder types: Other

Identifiers

NCT01158859

CRC09-014

Details and patient eligibility

About

The primary issue is to determine whether preoperatively administered pregabalin decreases the necessary dose of propofol during induction of general anesthesia. The investigators secondary issue is to test if preoperatively administered pregabalin decreases anxiety.

Enrollment: 50 estimated patients

Sex: Female

Ages: 18 to 40 years old

Volunteers: Accepts Healthy Volunteers

Inclusion criteria

• Laparoscopic gynaecologic surgery
• Age 18-40 years
• ASA class I or II
• Body mass index 18-30

Exclusion criteria

• Allergic to pregabalin or gabapentin
• Chronic renal failure
• Alcohol or drug abuse
• Chronic analgesic use other than acetaminophen or NSAID
• Already taking gabapentin, pregabalin, benzodiazepin or antidepression drug
• Known neurological deficiency
• Suspected difficult intubation or ventilation
• Atypical pseudocholinesterases

Trial design

Primary purpose: Treatment

Allocation: Randomized

Interventional model: Parallel Assignment

Masking: Quadruple Blind

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50 participants in 2 patient groups, including a placebo group

Pregabalin

Experimental group

Treatment:

Drug: Pregabalin

Placebo

Placebo Comparator group

Treatment:

Drug: Pregabalin