Effect of Prilocaine vs Bupivacaine on Hemodynamics in Spinal Anesthesia for Geriatric Patients

Cairo University (CU)

Status and phase: Completed; Phase 3

Conditions: Hemodynamic Instability

Treatments: Drug: Prilocaine; Drug: Bupivacaine

Study type: Interventional

Funder types: Other

Identifiers

NCT06165679

N-439-2023

Details and patient eligibility

About

Data comparing prilocaine vs bupivacaine in equipotent doses in the elderly are lacking; therefore, the study will compare the effect of prilocaine vs bupivacaine on hemodynamics in spinal anesthesia for geriatric patients undergoing endoscopic urological surgeries

Enrollment: 112 patients

Sex: All

Ages: 65+ years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• Patients aged 65 years old and above.
• Both genders.
• Patients scheduled to undergo endoscopic urological surgeries.
• ASA I and II class.

Exclusion criteria

• Patient refusal.
• Known local anesthetic (LA) allergy.
• Bleeding disorders.
• Skin lesions or infections at site of needle insertion.
• Hypertensive patients.
• Patients candidate for transurethral resection of the prostate
• ASA III and VI class

Trial design

Primary purpose: Prevention

Allocation: Randomized

Interventional model: Parallel Assignment

Masking: Double Blind

---

112 participants in 2 patient groups

Prilocaine group

Active Comparator group

Treatment:

Drug: Prilocaine

Bupivacaine GROUP

Active Comparator group

Treatment:

Drug: Bupivacaine