Effect of Probiotic Bacteria on Oral Candida in Frail Elderly
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About
The aim of this study is to investigate the effect of daily intake of the probiotic Lactobacillus Reuteri on the prevalence and counts of oral Candida in frail elderly living in nursery homes.
Full description
The aim of the present study was to investigate the effect of a twice daily intake of lozenges containing probiotic Lactobacillus reuteri on the prevalence and counts of oral Candida in senior residents living in nursery homes. The material consists of 215 elderly persons (range 60 to 102 years) living in 20 different nursery homes in the County of Kronoberg, situated in the southern parts of Sweden. The subjects were consecutively enrolled after informed consent consisting of verbal and written information directed to the individual as well as to their relatives. The study employed a double-blind randomized placebo-controlled design.
Enrollment
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Volunteers
Inclusion criteria
- non-smoking
- ability to cooperate with a dental examination and saliva sampling
Exclusion criteria
- severe chronic disease, malignancies or ongoing medication with immunosuppressive drugs
- severe dementia or cognitive impairment
Trial design
Primary purpose
Allocation
Interventional model
Masking
215 participants in 2 patient groups, including a placebo group
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Data sourced from clinicaltrials.gov
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