Effect of Probiotic on Constipation

China Agricultural University

Status and phase: Completed; Phase 3

Conditions: Constipation

Treatments: Dietary Supplement: Lactobacillus casei strain Shirota

Study type: Interventional

Funder types: Other

Identifiers

NCT03100851

CAUConstipation-01

Details and patient eligibility

About

Constipation is a prevalent intestinal disorder. Lactobacillus casei strain Shirota (LcS) shows potential effect on alleviating constipation. This study evaluated the impact of fermented milk containing LcS on stool consistency and frequency. The stool short chain fatty acid and gut microbiota were also assessed.

Enrollment: 62 patients

Sex: All

Ages: 18 to 45 years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• meet ROME Ⅲ criteria for functional constipation
• normal body mass index between 18.5 and 29.9

Exclusion criteria

• had a serious disease;
• used systemic antibiotics or antimycotics medication and antidiarrheal or laxative medication in the 30 days prior to the study;
• allergic to milk protein;
• constipated because of organic or neurological lesions;
• participated in any other studies within 2 months prior to this study.

Trial design

Primary purpose: Treatment

Allocation: N/A

Interventional model: Single Group Assignment

Masking: None (Open label)

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62 participants in 1 patient group

LcS intervention

Experimental group

Description:

Patients with constipation received dietary supplement with Lactobacaiilus casei strain Shirota.

Treatment:

Dietary Supplement: Lactobacillus casei strain Shirota