Effect of Probiotics as Supplement to Non-surgical Periodontal Treatment

University of Copenhagen

Status: Enrolling

Conditions: Periodontitis

Treatments: Dietary Supplement: Probiotic; Dietary Supplement: Placebo

Study type: Interventional

Funder types: Other

Identifiers

NCT05518747

UCPH_01_007

Details and patient eligibility

About

The present study is a double-blinded randomized clinical trial with a duration of 12 weeks.

Full description

The present study is a double-blinded randomized clinical trial with a duration of 12 weeks

. 60 patients with periodontitis stage 2-3, grade B-C, generalized will be allocated in the test (probiotic) and the control (placebo) group at baseline.

The intervention is non-surgical periodontal treatment, which will be applied at baseline and followed for 12 weeks.

Clinical measurements and sampling will be performed at baseline, week 6 and week 12.

Primary endpoint: Changes in microbial composition.

Secondary endpoints: Changes in clinical and immunological parameters

Enrollment: 60 estimated patients

Sex: All

Ages: 30 to 70 years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• Periodontitis stage 2-3, Grade B-C, generalized

Exclusion criteria

• • Use of systemic antibiotics within the latest three months.

Trial design

Primary purpose: Treatment

Allocation: Randomized

Interventional model: Parallel Assignment

Masking: Quadruple Blind

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60 participants in 2 patient groups, including a placebo group

Probiotic

Experimental group

Description:

In this group participants will receive non-surgical periodontal treatment at baseline, which will for 12 weeks

Treatment:

Dietary Supplement: Probiotic

Placebo

Placebo Comparator group

Description:

In this group participants will receive non-surgical periodontal treatment at baseline, which will for 12 weeks

Treatment:

Dietary Supplement: Placebo