Effect of Probiotics on Oral Candida Among Denture Wearers

Hams Hamed Abdelrahman

Status

Active, not recruiting

Conditions

Oral Candida Albicans Infection

Treatments

Other: Probiotic group

Other: Placebo group

Study type

Interventional

Funder types

Other

Identifiers

NCT05358743

probiotics_2022

Details and patient eligibility

About

Forty-eight denture wearers with detectable levels of candida colonization without clinical symptoms will be randomly allocated into two groups: probiotics and placebo. All patients will take a daily dose of chewable tablets (probiotics or placebo according to the assigned group) for 8 weeks. Samples of mouth rinse will be collected from patients at baseline, 4 weeks from the beginning of the intervention, 8 weeks (the end of intervention), and after another 4 weeks for post-intervention follow up. Samples will be tested for both candida count and candida species identification

Enrollment

50 estimated patients

Sex

All

Ages

40+ years old

Volunteers

No Healthy Volunteers

Inclusion criteria

Detectable levels of Candida in palatal mucosa without clinical symptoms of active candidiasis.
Completely edentulous arches with newly formed denture .
Patients with controlled hypertension, and diabetes will be included in this study as they are considered very common problems in the targeted population.

Exclusion criteria

Inability to understand/ follow the experimental procedures,
Administration of topic or systemic antifungal or antibacterial agents in the previous 60 days.
Consumption of probiotics.
GITdisorders.
Heartdisease.
Diseases that significantly influence immunity such as; kidney problems, head and neck cancer, or radiotherapy, AIDS, or immunosuppressive therapy.
Clinical manifestations of oral candidiasis.