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Effect of Prolonged GnRh Agonists on Results of Intracytoplasmic Sperm Injection (ICSI ) in Endometrioma Patients

K

Kasr El Aini Hospital

Status

Completed

Conditions

Endometrioma

Treatments

Procedure: standard long stimulation protocol
Drug: GnRh agonist ( Decapeptyl )
Procedure: endometrioma aspiration

Study type

Interventional

Funder types

Other

Identifiers

NCT02737800
obgynivf

Details and patient eligibility

About

Investigators compare ICSI results for endometrioma patients with or without cyst aspiration if more than 5cm &with or without GnRh agonists for all endometrioma patients

Full description

Group 1 consists of 30 patients of endometrioma more than 5cm subdivided into:

Group 1A;Cyst aspiration followed by standard long protocol in 15 patients Group 1B;Cyst aspiration followed by GnRh suppression for 3 months then standard long protocol in 15 patients

Group 2 consists of 30 patients of endometrioma less than 5cm subdivided into :

Group 2A;no intervention to the cyst. Standard long protocol Group 2B;GnRh suppression for 3 months then standard long protocol

Enrollment

88 patients

Sex

Female

Ages

18 to 40 years old

Volunteers

No Healthy Volunteers

Inclusion criteria

  • endometrioma patients

Exclusion criteria

  • Follicle stimulating hormone(FSH)10 or more
  • hydrosalpinx
  • GnRh suppression in the last 12 months

Trial design

Primary purpose

Treatment

Allocation

Randomized

Interventional model

Parallel Assignment

Masking

None (Open label)

88 participants in 4 patient groups

1A endometrioma more than 5cm
Active Comparator group
Description:
Endometrioma aspiration GnRh agonist :Decapeptyl 3.75mg intramuscular Standard long stimulation protocol \& ICSI
Treatment:
Procedure: endometrioma aspiration
Drug: GnRh agonist ( Decapeptyl )
Procedure: standard long stimulation protocol
1B endometrioma more than 5cm control
Sham Comparator group
Description:
Endometrioma aspiration Standard long stimulation protocol \& ICSI
Treatment:
Procedure: endometrioma aspiration
Procedure: standard long stimulation protocol
2A endometrioma less than 5cm
Active Comparator group
Description:
Decapeptyl 3.75mg intramuscular Standard long stimulation protocol \& ICSI
Treatment:
Drug: GnRh agonist ( Decapeptyl )
Procedure: standard long stimulation protocol
2B endometrioma less than 5cm control
Sham Comparator group
Description:
Standard long stimulation protocol \& ICSI
Treatment:
Procedure: standard long stimulation protocol

Trial contacts and locations

1

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Data sourced from clinicaltrials.gov

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