Effect of Prolonged GnRh Agonists on Results of Intracytoplasmic Sperm Injection (ICSI ) in Endometrioma Patients

Kasr El Aini Hospital

Status: Completed

Conditions: Endometrioma

Treatments: Procedure: standard long stimulation protocol; Drug: GnRh agonist ( Decapeptyl ); Procedure: endometrioma aspiration

Study type: Interventional

Funder types: Other

Identifiers

NCT02737800

obgynivf

Details and patient eligibility

About

Investigators compare ICSI results for endometrioma patients with or without cyst aspiration if more than 5cm &with or without GnRh agonists for all endometrioma patients

Full description

Group 1 consists of 30 patients of endometrioma more than 5cm subdivided into:

Group 1A;Cyst aspiration followed by standard long protocol in 15 patients Group 1B;Cyst aspiration followed by GnRh suppression for 3 months then standard long protocol in 15 patients

Group 2 consists of 30 patients of endometrioma less than 5cm subdivided into :

Group 2A;no intervention to the cyst. Standard long protocol Group 2B;GnRh suppression for 3 months then standard long protocol

Enrollment: 88 patients

Sex: Female

Ages: 18 to 40 years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• endometrioma patients

Exclusion criteria

• Follicle stimulating hormone(FSH)10 or more
• hydrosalpinx
• GnRh suppression in the last 12 months

Trial design

Primary purpose: Treatment

Allocation: Randomized

Interventional model: Parallel Assignment

Masking: None (Open label)

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88 participants in 4 patient groups

1A endometrioma more than 5cm

Active Comparator group

Description:

Endometrioma aspiration GnRh agonist :Decapeptyl 3.75mg intramuscular Standard long stimulation protocol \& ICSI

Treatment:

Procedure: endometrioma aspiration

Drug: GnRh agonist ( Decapeptyl )

Procedure: standard long stimulation protocol

1B endometrioma more than 5cm control

Sham Comparator group

Description:

Endometrioma aspiration Standard long stimulation protocol \& ICSI

Treatment:

Procedure: endometrioma aspiration

Procedure: standard long stimulation protocol

2A endometrioma less than 5cm

Active Comparator group

Description:

Decapeptyl 3.75mg intramuscular Standard long stimulation protocol \& ICSI

Treatment:

Drug: GnRh agonist ( Decapeptyl )

Procedure: standard long stimulation protocol

2B endometrioma less than 5cm control

Sham Comparator group

Description:

Standard long stimulation protocol \& ICSI

Treatment:

Procedure: standard long stimulation protocol