Effect of Prophylaxy of Amiodarone and Propranolol and Amiodarone With Propranolol in Prevention of Atrial Fibrillation Post Coronary Artery Bypass Graft

Shiraz University of Medical Sciences

Status: Completed

Conditions: Atrial Fibrillation

Treatments: Drug: Propranolol; Drug: Amiodarone; Drug: Amiodarone + Propranolol

Study type: Interventional

Funder types: Other

Identifiers

NCT00654290

55318

NIH of IRAN

Details and patient eligibility

About

Atrial fibrillation is the most common arrhythmia post coronary bypass surgery, currently B-blockers are the class I indication to prevent AF post CABG. We decide to evaluate use of propranolol and amiodarone separately and together to find a better prophylaxis for AF peri-CABG

Full description

In this double blind randomized study 240 consecutive patients underwent elective coronary artery bypass grafting, being randomized prospectively into three groups, propranolol (p) (n=80), amiodarone (A) (n=80) and amiodarone with propranolol (AP) (n=80).

All groups received their medications from 7 days preoperatively and continued their medications for 5 days post CABG.

Enrollment: 240 patients

Sex: All

Ages: 45 to 70 years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• Patient who are going to have elective CABG
• Signing informed consent

Exclusion criteria

• EF<35%
• Bradycardia<60 per min
• Hypotension< 100 mmhg

Trial design

Primary purpose: Prevention

Allocation: Randomized

Interventional model: Parallel Assignment

Masking: Quadruple Blind

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240 participants in 3 patient groups

P

Experimental group

Description:

Propranolol from 7 days pre-operation to 5 days post CABG

Treatment:

Drug: Propranolol

A

Active Comparator group

Description:

Amiodarone treated 7 days pre-operation to 5 days post CABG

Treatment:

Drug: Amiodarone

AP

Active Comparator group

Description:

Amiodarone and Propranolol 7 days pre-operation to 5 days post CABG

Treatment:

Drug: Amiodarone + Propranolol