Effect of Propofol on Remifentanil-induced Postoperative Hyperalgesia in Patients Undergoing Thyroid Surgery

Yonsei University Health System (YUHS)

Status and phase: Unknown; Phase 4

Conditions: Hyperalgesia

Treatments: Drug: propofol, sevoflurane

Study type: Interventional

Funder types: Other

Identifiers

NCT01189721

3-2010-0102

Details and patient eligibility

About

The investigators hypothesize that propofol infusion during surgery can affect the remifentanil hyperalgesia compared to sevoflurane inhalation.The outcome will be measured by a verbal numerical rating score (VNRS) and mechanical punctuating pain by electronic von frey filament.

Enrollment: 84 estimated patients

Sex: All

Ages: 20 to 65 years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• Patients undergoing thyroidectomy
• Age 20-65
• American Society of Anesthesiologists physical status classification I or II

Exclusion criteria

• History of chronic pain, Regular use of analgesic, antiepileptic or antidepressive drugs
• History of drug & alcohol abuse
• Psychiatric disorder
• Use of opioids within 24hrs
• Renal disease with decreased glomerular filtrate ratio
• Neuromuscular disease, Severe cardiac disease

Trial design

Primary purpose: Treatment

Allocation: Randomized

Interventional model: Parallel Assignment

Masking: Quadruple Blind

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84 participants in 2 patient groups

sevoflurane

Active Comparator group

Description:

Remifentanil will be infused intraoperatively at 0.2 ㎍/㎏/min. patients who are in this group will be infused propofol intraoperatively.

Treatment:

Drug: propofol, sevoflurane

propofol

Experimental group

Description:

Remifentanil will be infused intraoperatively at 0.2 ㎍/㎏/min. patients included this group will be inhaled sevoflurane intraoperatively.

Treatment:

Drug: propofol, sevoflurane