Effect of Protein From Animal and Vegetable Sources on Appetite (PAVA)

Arne Astrup

Status: Completed

Conditions: Focus of Study: Appetite

Treatments: Other: Vegetable Protein; Other: Animal protein

Study type: Interventional

Funder types: Other

Identifiers

NCT01345487

B275

Details and patient eligibility

About

New Nordic diet guidelines advocate a reduction in consumption of protein from animal sources such as beef and pork, due to environmental concerns. Instead, intake of protein from vegetable sources such as legumes and pulses should be increased. However, little is known about the effect of protein from (Nordic grown) beans and peas on body weight and appetite regulation.

The objective of this study is to examine if protein from vegetable sources (beans and peas) is comparable to protein from animal sources regarding acute meal-induced satiety.

Full description

Design:

Single-blind randomized 3-way crossover meal study

Subjects:

• 48 young healthy men (Age: 18-50 years; BMI: 19-30 kg/m2).
• Expected completers: n=42.

End points:

• Subjective appetite (VAS) (every 30 min for 3 hours)
• Ad libitum energy intake (3 hours after test meal)

Experimental diets:

Iso-caloric breakfast meals (3.5 MJ) with same energy density:

A. Fava beans + Split peas (20 protein E%) B. Fava beans + Split peas + potato (10 protein E%) C. Pork/beef + potato (20 protein E%)

Enrollment: 48 patients

Sex: Male

Ages: 18 to 50 years old

Volunteers: Accepts Healthy Volunteers

Inclusion criteria

• healthy men
• 18-50 y
• body mass index (BMI) 18.5-30.0

Exclusion criteria

• smoking
• participation in other studies for 4 mo prior to entry
• weight gain/loss > 3 kg for to mo prior to entry
• Strenuous physical activity for > 10 h/wk
• Use of medication that can affect appetite
• food allergies or relevance for the test meals
• Psychiatric or metabolic disorders prohibiting participation

Trial design

Primary purpose: Prevention

Allocation: Randomized

Interventional model: Crossover Assignment

Masking: Single Blind

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48 participants in 3 patient groups

Low Vegetable Protein

Other group

Description:

Meal with 10 E% protein from fava beans/split peas

Treatment:

Other: Vegetable Protein

High Vegetable protein

Experimental group

Description:

Meal with 20 E% protein from fava beans/split peas

Treatment:

Other: Vegetable Protein

High Animal Protein

Experimental group

Description:

Meal with 20 E% protein from pork/beef

Treatment:

Other: Animal protein