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Effect of PRP Joint Cavity Combined with Acupoint Injection on Osteoarthritis of Knee Joint

Z

Zhengzhou Revo-Gene Technology Co., LTD

Status

Completed

Conditions

Early Knee Osseous Arthrophlogosis

Treatments

Other: PRP joint injection combined with acupoint injection

Study type

Interventional

Funder types

NETWORK

Identifiers

Details and patient eligibility

About

This study collected general data from 90 patients with KOA in the outpatients and ward of Henan Provincial People's Hospital from January 2023 to December 2023 to compare the long-term effects of intra-articular PRP combined with acupoint PRP, intra-articular PRP, and intra-articular HA on symptoms in patients with mild to moderate osteoarthritis

Enrollment

90 patients

Sex

All

Ages

18 to 80 years old

Volunteers

No Healthy Volunteers

Inclusion criteria

  1. The expected survival period is more than 3 months;
  2. The clinical diagnosis was early knee osteoarthritis;
  3. Capable of knee injections;
  4. chronic joint pain or swelling (> 4 months);
  5. It meets the diagnostic criteria of the Chinese Guidelines for the Diagnosis and Treatment of Osteoarthritis (2021 Edition) , and the X-ray evaluation results meet the Kellgren-Lawrence scale (K-L scale) level I to level III.

Exclusion criteria

  1. age over 80 years old;
  2. K-L classification is greater than Ⅲ grade;
  3. Combined with rheumatoid arthritis, severe osteoporosis, tumor, gout, obvious joint deformity and other diseases;
  4. Poor compliance, not according to the provisions of treatment;
  5. Pregnant and lactating women;
  6. Patients voluntarily withdrew from the study;
  7. Patients were lost to follow-up due to various reasons during follow-up.

Trial design

Primary purpose

Treatment

Allocation

Randomized

Interventional model

Parallel Assignment

Masking

Single Blind

90 participants in 3 patient groups, including a placebo group

HA group
No Intervention group
Description:
treated with intra-articular injection of hyaluronic acid solution, 2 ml per injection, and 1 ml of normal saline injection at Xuehai, Yanglingquan, and Weizhong acupoints at the same time, once a week for 4 weeks
PRP joint injection group
Placebo Comparator group
Description:
treated with intra-articular injection of PRP, 3.5 ml per injection, and 1 ml of normal saline injection at Xuehai, Yanglingquan, and Weizhong acupoints at the same time, once a week for 4 weeks
Treatment:
Other: PRP joint injection combined with acupoint injection
PRP joint injection combined with acupoint injection group
Experimental group
Description:
treated with intra-articular injection of PRP, 3.5 ml per injection, and 1 ml of PRP injection at Xuehai, Yanglingquan, and Weizhong acupoints at the same time, once a week for 4 weeks
Treatment:
Other: PRP joint injection combined with acupoint injection

Trial contacts and locations

1

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Data sourced from clinicaltrials.gov

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