Effect of Pyridorin in Patients With Diabetic Nephropathy

BioStratum

Status and phase: Completed; Phase 2

Conditions: Diabetic Nephropathy

Treatments: Drug: Pyridorin (pyridoxamine dihydrochloride)

Study type: Interventional

Funder types: Industry

Identifiers

NCT00320021

PYR-205/207

PYR-205

PYR-207

Details and patient eligibility

About

The primary objective of the study is to evaluate the safety, tolerability and efficacy of Pyridorin (pyridoxamine dihydrochloride) up to 250 mg given orally twice daily in patients with diabetic kidney disease.

Sex: All

Ages: 18 to 70 years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• Males and Females (non-pregnant and non-lactating) between 18 and 70 years of age with type 1 or type 2 diabetes

• Sitting blood pressure of <=170/100 mm Hg at weeks -2 and -1

• Hemoglobin A1C <=12% at week -2

• Patients with diagnosis of diabetic nephropathy as defined by

  1. Serum Creatinine <=2.0 mg/dL at weeks -2 and -1 (PYR-205) Serum Creatinine >2.0 mg/dL but <=3.5 mg/dL at weeks -2 and -1 (PYR-207)
  2. Urinary albumin excretion >=300 mg/24 hours at week -2
  3. No other known or suspected etiology for nephropathy

• Voluntary written consent to participate in this study

Exclusion criteria

• History of allergic or adverse response to any B vitamin
• History of major cardiovascular or cerebrovascular events
• History of cancer except adequately treated basal or squamous cell carcinoma of the skin
• History of diabetic ketoacidosis
• Autoimmune diseases
• History of significant peripheral neuropathy

Trial design

Primary purpose: Treatment

Allocation: Randomized

Interventional model: Parallel Assignment

Masking: Double Blind