Effect of Quercetin in Prevention and Treatment of Oral Mucositis

Mashhad University of Medical Sciences

Status and phase: Completed; Phase 2; Phase 1

Conditions: Chemotherapy Induced Oral Mucositis

Treatments: Drug: Placebo; Drug: oral quercetin capsules

Study type: Interventional

Funder types: Other

Identifiers

NCT01732393

89470

Details and patient eligibility

About

The study aims to evaluate the effect of Quercetin (a natural flavonoid) on prevention of and treatment of chemotherapy-induced oral mucositis in patients with blood malignancies.

Enrollment: 20 patients

Sex: All

Ages: 15 to 40 years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• patient under chemotherapy
• for a hematologic malignancy
• the hematologist permits the trial on the patient
• agreement of patient for participating in the trial

Exclusion criteria

• presence pf ANY oral lesion at the beginning of the trial
• loss of follow up
• use of digoxin and cyclosporine
• patient death

Trial design

Primary purpose: Treatment

Allocation: Randomized

Interventional model: Parallel Assignment

Masking: Quadruple Blind

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20 participants in 2 patient groups, including a placebo group

oral quercetin capsules

Active Comparator group

Description:

Patients in the intervention group were administered two, 250 mg Quercetin capsules daily for 3 weeks

Treatment:

Drug: oral quercetin capsules

oral placebo capsules

Placebo Comparator group

Description:

Patients in the placebo group received two placebo capsules containing lactose .

Treatment:

Drug: Placebo