Effect of Quercetin on Prophylaxis and Treatment of COVID-19

Kanuni Sultan Suleyman Training and Research Hospital

Status: Completed

Conditions: COVID-19

Treatments: Dietary Supplement: Quercetin Treatment; Dietary Supplement: Quercetin Prophylaxis

Study type: Interventional

Funder types: Other

Identifiers

NCT04377789

KSSEAH--0058

Details and patient eligibility

About

Novel Coronavirus is defined to be the cause of COVID-19, recently. It's known that COVID-19 goes with excessive immune reaction of human body in severe cases. The investigators hypothesize that quercetin, as a strong scavenger and anti-inflammatory agent, can be effective on both prophylaxis and treatment of COVID-19 cases. Therefore, the aim of this study to evaluate the possible role of quercetin on prophylaxis and treatment of COVID-19.

Full description

Novel Coronavirus is defined to be the cause of COVID-19, recently. It's known that COVID-19 goes with excessive immune reaction of human body in severe cases. Quercetin is reported to be effective on treatment and prophylaxis of other SARS like coronavirus infections, as a strong antioxidant and scavenger flavonoid without any adverse events. Upon this data, the investigators hypothesize that quercetin can be effective on both prophylaxis and treatment of COVID-19 cases. Therefore, the aim of this study to evaluate the possible role of quercetin on prophylaxis and treatment of COVID-19.

Enrollment: 447 patients

Sex: All

Ages: 18+ years old

Volunteers: Accepts Healthy Volunteers

Inclusion criteria

• moderate-high risk for COVID-19
• obtained informed consent

Exclusion criteria

• declined to participate
• genetic/chromosomal abnormalities
• any kind of sensitivity or allergy for quercetin
• history of previous hypersensitivity with quercetin

Trial design

Primary purpose: Prevention

Allocation: Randomized

Interventional model: Parallel Assignment

Masking: None (Open label)

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447 participants in 3 patient groups

non-quercetin group

No Intervention group

Description:

Participants, who accept to enroll the study without having quercetin prophylaxis and who do not have a history of COVID-19, will be in this group.

quercetin prophylaxis group

Active Comparator group

Description:

Participants, who takes a daily dose of 500mg quercetin and who not have a history of COVID-19, will be in this group.

Treatment:

Dietary Supplement: Quercetin Prophylaxis

quercetin treatment group

Active Comparator group

Description:

Participants, who takes a daily dose of 1000mg quercetin and who are proven cases for COVID-19, will be in this group.

Treatment:

Dietary Supplement: Quercetin Treatment