Effect of Radiofrequency Ablation in Patients With Ventricular Arrhythmia Undergoing CABG (RACAVA)

Capital Medical University

Status: Unknown

Conditions: MI Related Malignant Ventricular Arrhythmia

Treatments: Procedure: CABG; Procedure: unipolar or bipolar radiofrequency ablation+CABG

Study type: Interventional

Funder types: Other

Identifiers

NCT02991170

XMLX201504

Details and patient eligibility

About

Patients with myocardial infarction related potential malignant ventricular arrhythmia have high risk of sudden death. The aim of this clinical trial is evaluating therapeutic efficacy of unipolar or bipolar radiofrequency ablation in Coronary Artery Bypass Grafts (CABG) Surgery, which can reduce myocardial ischemia and block reentry circuits of ventricular arrhythmia at the same time. The observation indexes include the morbidity of potential malignant ventricular arrhythmia and major adverse cardiovascular events in mid-long-term after CABG surgery.

Enrollment: 180 estimated patients

Sex: All

Ages: 45 to 75 years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• The patients have been receiving coronary artery bypass grafts from 2015.1-2017.12
• The patients had old myocardial infarction related potential malignant ventricular arrhythmia
• Anti-arrhythmic drug treatment is invalid
• All enrolled patients must being signed the informed consent

Exclusion criteria

• Severe heart failure( ejection fraction under 35%)
• Patients with acute myocardial infarction
• Patients with ICD implanted

Trial design

Primary purpose: Treatment

Allocation: Non-Randomized

Interventional model: Parallel Assignment

Masking: None (Open label)

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180 participants in 2 patient groups

control group

Active Comparator group

Description:

Patients with myocardial infarction related potential malignant ventricular arrhythmia undergoing Coronary Artery Bypass Grafts

Treatment:

Procedure: CABG

interventional group

Experimental group

Description:

Patients with myocardial infarction related potential malignant ventricular arrhythmia undergoing unipolar or bipolar radiofrequency ablation and Coronary Artery Bypass Grafts at the same time

Treatment:

Procedure: unipolar or bipolar radiofrequency ablation+CABG