Effect of Radioiodine Therapy on Ovarian Reserve in Female Patients With Differentiated Thyroid Cancer

Assiut University

Status: Unknown

Conditions: Ovarian Insufficiency; Radiation Exposure

Treatments: Radiation: radioactive iodine

Study type: Interventional

Funder types: Other

Identifiers

NCT04396158

ovarian reserve

Details and patient eligibility

About

Thyroid carcinoma is the most common endocrine malignancy. Surgery is the standard therapeutic approach for patients with differentiated thyroid carcinoma (DTC), followed by radioiodine (RAI) therapy if indicated. For women with DTC, the effects of RAI therapy on gonadal and reproductive function are an important consideration. This study aimed to evaluate the effects of RAI therapy on ovarian function.

Enrollment: 38 estimated patients

Sex: Female

Ages: 15 to 45 years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• Female patient in childbearing period.
• Female patient with differentiated thyroid carcinoma.
• Underwent thyroidectomy.
• Candidate for radioactive iodine therapy.

Exclusion criteria

• • Male patients.

  • Postmenopausal female patients.
  • Female patients with undifferentiated thyroid carcinoma.
  • Pregnant female patients.
  • Lactating female patients.

Trial design

Primary purpose: Diagnostic

Allocation: N/A

Interventional model: Single Group Assignment

Masking: None (Open label)

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38 participants in 1 patient group

intervention

Experimental group

Treatment:

Radiation: radioactive iodine