Effect of Ramadan Fasting on Ovulation and Insuline Resistance in Patients With PCOS

Ain Shams University

Status: Unknown

Conditions: Polycystic Ovary Syndrome

Study type: Observational

Funder types: Other

Identifiers

NCT02499289

PCOS FASTING

Details and patient eligibility

About

Polycystic ovary syndrome (PCOS) has a heterogeneous clinical presentation comprising reproductive (hyperandrogenism, menstrual irregularity, anovulation, infertility, pregnancy complications), metabolic [insulin resistance (IR), increased type 2 diabetes mellitus (T2DM) and cardiovascular disease (CVD) risk factors] and psychological features (worsened quality of life and increased anxiety and depression) Whether prolonged fasting during Ramadan breaks the insulin resistance state of polycystic ovarian syndrome and subsequently improve the ovulation and spontaneous pregnancy will happen without ovarian stimulation.

Full description

Question of the study:

The question is raised whether prolonged fasting during Ramadan breaks the insulin resistance state of polycystic ovarian syndrome and improve the metabolic syndrome does prolonged fasting decrease glucose level, insulin level, insulin resistance markers such as adipokines and subsequently improve ovarian function and causes spontaneous ovulation.

Enrollment: 80 estimated patients

Sex: Female

Ages: 18 to 40 years old

Volunteers: Accepts Healthy Volunteers

Inclusion criteria

• Females with PCO in child bearing age who presented at reproductive and endocrinology clinics at Ain Shams University Maternity Hospital, and welling to fast for 30 days from 5 am until 7 pm and do not plan to induce her ovulation in the next 4 months to get pregnant.
• Does not have any other medical illnesses other than PCO.
• Welling not to start any ovulation induction in the next 4 months after the first blood sample was taken and after fasting month.

Exclusion criteria

• Known androgen secreting tumor.
• PCO on ovarian stimulation medications
• PCO with any other medical illness.
• Non-compliance with fasting 30 days from 5 am- 7 pm.