Effect of Ramosetron on Post-discharge Nausea and Vomiting

Seoul National University

Status: Unknown

Conditions: Hysteroscopy

Treatments: Drug: Normal saline; Drug: Ramosetron

Study type: Interventional

Funder types: Other

Identifiers

NCT03409835

PDNV

Details and patient eligibility

About

Nausea and vomiting after general anesthesia is one of the common anesthetic complications. If the patient is discharged from the hospital after surgery, proper treatment may be delayed or impossible if nausea or vomiting occurs. Thus, It is necessary to prevent these symptoms beforehand. Patients who underwent gynecologic surgery will be treated with prophylactic ramosetron to determine whether the frequency of nausea and vomiting is decreased when the patient returned home after discharge.

Enrollment: 100 estimated patients

Sex: Female

Ages: 20 to 60 years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• Patients who undergo hysteroscopic surgery and are discharged on the day of surgery.

Exclusion criteria

• American Society of Anesthesiologists physical statue 3 or more
• Planned admission after surgery
• Intravenous anesthesia
• During chemotherapy
• Pregnancy or breastfeeding
• Abnormal liver or kidney function

Trial design

Primary purpose: Prevention

Allocation: Randomized

Interventional model: Parallel Assignment

Masking: Quadruple Blind

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100 participants in 2 patient groups, including a placebo group

Ramosetron

Experimental group

Treatment:

Drug: Ramosetron

Control

Placebo Comparator group

Treatment:

Drug: Normal saline