Effect of Rapeseed Oil and Sunflower Oil

Medical University of Vienna

Status: Unknown

Conditions: Familial Hypercholesterolemia

Treatments: Dietary Supplement: sunflower oil; Dietary Supplement: rapeseed oil

Study type: Interventional

Funder types: Other

Identifiers

NCT00924274

EROSO

Details and patient eligibility

About

Familial hypercholesterolemia (FH), an inherited disorder of lipoprotein metabolism, is a risk for early cardiovascular disease (CVD). This autosomal dominant disease is characterized by markedly elevated plasma concentrations of low density lipoprotein (LDL) and total cholesterol (TC). The purpose of this study is to compare the effect of a diet low in saturated fats but enriched either with rapeseed oil (RO) or sunflower oil (SO) in children and adolescents with FH on serum lipoproteins.

Enrollment: 24 estimated patients

Sex: All

Ages: 6 to 18 years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• chilren and adolescents between 6 and 18 years of age
• LDLc > 130 mg/dl and
• TC > 200 mg/dl
• 7 day nutrition record
• written informed consent

Exclusion criteria

• overweight
• underweight
• mental disability
• drug therapy

Trial design

Primary purpose: Treatment

Allocation: Randomized

Interventional model: Parallel Assignment

Masking: Triple Blind

---

24 participants in 2 patient groups

Lifestyle counseling

Experimental group

Treatment:

Dietary Supplement: rapeseed oil

sunflower oil

Active Comparator group

Treatment:

Dietary Supplement: sunflower oil