Effect of Rapid Transfusion With Fluid Management System 2000® (FMS)

Seoul National University

Status: Completed

Conditions: Liver Transplantation

Treatments: Device: Fluid management system 2000 (FMS)

Study type: Interventional

Funder types: Other

Identifiers

NCT01448343

CWJung_FMS

Details and patient eligibility

About

Rapid infusion of red blood cells is known to result in the increase of plasma potassium. The researchers are trying to investigate the change in plasma potassium during rapid infusion of mixed blood components in the reservoir of the fluid management system (FMS) in liver transplant recipients.

Full description

FMS is a standard equipment to prepare for the massive bleeding during the liver transplant surgery. This device usually delivers a mixture of red blood cell (RBC), fresh frozen plasma and normal saline. Rapid infusion of RBC is known to result in the increase of potassium and the decrease of calcium in the plasma of the patient. However there is no report about the consequence of rapid transfusion of the blood mixture in the reservoir of the FMS, especially in the liver transplantation recipients. The primary end point of this study is to investigate the change in the plasma potassium and to assess the possibility of hyperkalemia and related morbidity. Changes of blood pH and plasma calcium will also be sought.

Enrollment: 10 patients

Sex: All

Ages: 16 to 80 years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• liver transplantation recipients

Exclusion criteria

• hemoglobin > 10 g/dL before surgery
• renal failure
• hyperkalemia
• chronic hyponatremia
• cardiac dysfunction

Trial design

Primary purpose: Diagnostic

Allocation: N/A

Interventional model: Single Group Assignment

Masking: Single Blind

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10 participants in 1 patient group

FMS

Experimental group

Description:

Patients who received blood transfusion using FMS

Treatment:

Device: Fluid management system 2000 (FMS)