Effect of Re-education on Rebleeding Rate After Endoscopic Treatment in Liver Cirrhosis

Shandong University

Status: Unknown

Conditions: Liver Cirrhosis; Esophageal Varices Bleeding; Gastric Variceal Bleeding; Bleeding

Treatments: Behavioral: re-education

Study type: Interventional

Funder types: Other

Identifiers

NCT05302661

20211013-Li

Details and patient eligibility

About

A prospective, randomized controlled study on whether re-education after discharge can reduce the rebleeding rate after endoscopic treatment of esophageal and gastric varices in patients with liver cirrhosis

Full description

After receiving esophageal variceal ligation and （or） gastric fundus variceal sclerotherapy, patients with outside hospitalthe rate of bleeding due to liver cirrhosis shall be re-educated outside the hospital, including diet, drugs, anticoagulation of portal vein thrombosis,regular endoscopic treatment, reexamination , nutrition, etc. The patients were divided into the first treatment group and the more thanonce treatment group according to whether they had received endoscopic treatment in the past

Enrollment: 508 estimated patients

Sex: All

Ages: 18 to 75 years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• Esophageal and / or gastric varices ；
• liver cirrhosis ；
• patients receiving endoscopic treatment (esophagogastric variceal sclerosis and/or ligation) ；
• All subjects or their guardians must sign the subject consent form before entering the test

Exclusion criteria

• Patients with mental illness, severe hearing loss and unable to take care of themselves ;
• ASA score ≥ grade IV at discharge ;
• Hepatic encephalopathy ≥ stage II;
• Patients with liver cancer;
• Pregnant and lactating women;
• Patients who cannot sign informed consent

Trial design

Primary purpose: Treatment

Allocation: Randomized

Interventional model: Parallel Assignment

Masking: Single Blind

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508 participants in 2 patient groups

case group will receive re-education after leave hospital

Experimental group

Description:

The participants were randomly divided into re-education group and non re-education group according to the random number table. The re-education group will receive regular re-education not noly when they leave hospital but also after leave hospital in our preset time by telephone or wechat. The content of re-education includes diet form and diet structure,medication compliance and regularity, and recheck compliance, moderate exercise and so on

Treatment:

Behavioral: re-education

control case group will receive no re-education after leave hospital

No Intervention group

Description:

The participants were randomly divided into re-education group and non re-education group according to the random number table. without re-education group will receive regular re-education when they leave hospital.The content of re-education includes diet form and diet structure,medication compliance and regularity, and recheck compliance, moderate exercise and so on