Effect of Reconditioning Exercise on Older Adults With Urinary Tract Cancer Following Curative Surgery

National Cheng Kung University

Status: Completed

Conditions: Rehabilitation

Treatments: Other: Health education; Other: Rehabilitation

Study type: Interventional

Funder types: Other

Identifiers

NCT04999345

A-ER-109-415

Details and patient eligibility

About

As population ages, geriatric patients with urinary tract cancer suffer from more complications and functional decline that alter treatment plan despite advance in cancer surgery. It was found that these urinary tract cancer survivors required a longer time to recover to the state before the treatment, and some may be even unable to recover to the state before the treatment. Exercise intervention has been found to be beneficial to improve functional capacity for cancer survivors, such as breast cancer. However, it is unclear whether exercise intervention could also improve functional recovery and mobility in patients with urinary tract cancer following curative surgery, especially in older adults. The purpose of this study is to investigate the effect of reconditioning exercise on morbidity, oncological outcomes, and functional recovery in older adults with urinary tract cancer following curative surgery.

Patients aged over 65 years old and after having undergone curative surgery for confirmed urinary tract cancer will be recruited. The participants will be assigned into two groups using blocked randomization design. One group will receive reconditioning exercise training for five consecutive days, and the other group will receive exercise education. Structured questionnaire for comprehensive geriatric assessment and functional mobility, such as walking performance, will be used to assess the training effect. Outcome measures are assessed including major complication after surgeries, changes in functional status, tumor progression, and length of survival. Physical function measurement will include hand grip, muscle strength of lower extremities, and gait performance.

Enrollment: 32 patients

Sex: All

Ages: 65 to 100 years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• after having undergone curative surgery for confirmed urinary tract cancer
• able to independently walk for at least 8 meters before surgery
• able to follow 3-step commands

Exclusion criteria

• having unstable medical conditions or metastasis
• having neuromuscular diseases, such as stroke, Parkinson's diseases
• unable to attend training sessions
• having other health issues which would interfere evaluation and exercise training

Trial design

Primary purpose: Treatment

Allocation: Randomized

Interventional model: Parallel Assignment

Masking: None (Open label)

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32 participants in 2 patient groups, including a placebo group

Experimental Group

Experimental group

Description:

Provide resistance and aerobic exercise

Treatment:

Other: Rehabilitation

Control Group

Placebo Comparator group

Description:

Health education and gross range of motion exercise for upper and lower extremities

Treatment:

Other: Health education