Effect of Reducing Uric Acid on Insulin Sensitivity and Oxidative Status (UA)

The Washington University

Status: Completed

Conditions: Hyperuricemia; Obesity; Metabolic Syndrome

Treatments: Drug: Rasburicase

Study type: Interventional

Funder types: Other

Identifiers

NCT01931527

06-0509 / 201104189

Details and patient eligibility

About

The purpose of this study is to learn more about what is the effect of uric acid on oxidative stress and on the way the body metabolizes sugar in obese people. Understanding this may lead to better diseases such as diabetes.

Full description

It has been hypothesized that oxidative stress is involved in the pathogenesis of insulin resistance associated with obesity. Circulating uric acid (UA) is the body's major endogenous plasma antioxidant. Therefore, the investigators evaluated whether alterations in serum UA concentration affect: 1) systemic and skeletal muscle oxidative stress, 2) total antioxidant capacity, and 4) skeletal muscle insulin sensitivity during a hyperinsulinemic-euglycemic clamp.

Enrollment: 31 patients

Sex: All

Ages: 18 to 65 years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• obese (BMI 30-45 kg/m²);
• serum UA concentration either ≥5 mg/dL or ≤4.0 mg/dL (297 µmol/L)],

Exclusion criteria

• renal dysfunction (serum creatinine >1.5 mg/dL);
• pregnancy or lactating;
• take urate-lowering agents, thiazide diuretics, prednisone or medications containing aspirin or other salicylates;
• history of xanthinuria, type 2 diabetes or other significant organ system dysfunction;
• have G6PD deficiency;
• use hormone-replacement or oral-contraceptive therapy;
• smoke tobacco;
• anemic (Hb <10 g/dl)

Trial design

Primary purpose: Other

Allocation: Non-Randomized

Interventional model: Single Group Assignment

Masking: None (Open label)

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31 participants in 2 patient groups

Obese subjects with normal uric acid

No Intervention group

Description:

Subjects with a body mass index = or \> 30 kg/m² with normal uric acid (= or \< 5 mg/dL)

Obese subjects with high uric acid

Experimental group

Description:

Subjects with a body mass index = or \> 30 kg/m² with high uric acid (\>6 mg/dL) Intervention: one single infusion of rasburicase (0.19 mg/kg FFM) infused over 30 min

Treatment:

Drug: Rasburicase