Effect of Reduction of Inflammatory Status on Glucose Metabolism in Overweight Men

Netherlands Organisation for Applied Scientific Research (TNO)

Status: Completed

Conditions: Inflammation; Overweight; Obesity

Treatments: Drug: Diclofenac

Study type: Interventional

Funder types: Other

Identifiers

NCT00221052

TNO-P6374

Details and patient eligibility

About

Overweight increases the risk to develop chronic diseases including type-2 diabetes and cardiovascular disease. The low-grade inflammatory status often seen in overweight subjects is thought to play an important role in disease development.

The purpose of this study is to determine the role of inflammation on glucose metabolism and insulin resistance. In this study the effect of the anti-inflammatory treatment diclofenac on markers of inflammation and on parameters of glucose metabolism will be studied.

Sex: Male

Ages: 18 to 60 years old

Volunteers: Accepts Healthy Volunteers

Inclusion criteria

• Body Mass Index (BMI): 25.1 - 32.0 kg/m2
• Normal Dutch eating habits

Exclusion criteria

• diabetes, cardiovascular disease or hypertension
• Not suitable to receive diclofenac treatment
• Smoking
• Extreme physical activity (more than 6 hours/week)
• Reported slimming or medically prescribed diet