Effect of Regional Versus General Anesthesia on Thirty-day Outcomes Following Carotid Endarterectomy: a Matched-pairs Cohort Study.

University of Virginia

Status: Completed

Conditions: Perioperative/Postoperative Complications; Regional Anesthesia Morbidity; Carotid Artery Diseases

Treatments: Procedure: Anesthetic technique (regional versus general)

Study type: Observational

Funder types: Other

Identifiers

NCT05706688

HSRZOKZZ

Details and patient eligibility

About

The goal of this observational study is to assess the effect of regional versus general anesthesia on carotid endarterectomy thirty-day outcomes. The main questions it aims to answer are:

• Is regional anesthesia associated with lower incidence of major morbidity and mortality?
• Is regional anesthesia associated with lower incidences of secondary adverse events?

Participants will be sampled from the 2015-2019 American College of Surgeons National Surgical Quality Improvement Program

Enrollment: 37,204 patients

Sex: All

Ages: 18+ years old

Volunteers: Accepts Healthy Volunteers

Inclusion criteria

• Elective, non-emergent cases
• Regional anesthesia
• General anesthesia

Exclusion criteria

• Concurrency in procedures
• Acute kidney injury (preoperative)
• End-stage renal disease (preoperative)
• Metastatic disease (preoperative)
• Wound infection (preoperative)
• Sepsis (preoperative)
• ASA 5

Trial design

37,204 participants in 2 patient groups

Regional anesthesia

Description:

4,152 patients undergoing elective carotid endarterectomy under regional anesthesia

Treatment:

Procedure: Anesthetic technique (regional versus general)

General anesthesia

Description:

4,152 matched controls undergoing elective carotid endarterectomy under general anesthesia

Treatment:

Procedure: Anesthetic technique (regional versus general)