Effect of Rehabilitation at Moderate Altitude on Airway Resistance Measured With Forced Oscillation Technique in COPD-patients

Eastern Switzerland University of Applied Sciences

Status

Enrolling

Conditions

COPD

Treatments

Other: ambiant air

Other: Oxygen

Study type

Interventional

Funder types

Other

Identifiers

NCT07063563

inRehaExO2_FOT

Details and patient eligibility

About

Airway resistance will be measured using the forced oscillation technique (FOT). The parameters Rrs, Xrs, and ∆Xrs will be compared before and after a pulmonary rehabilitation cycle at moderate altitude. Additionally, the differences between low and moderate altitude will also be examined.

Enrollment

52 estimated patients

Sex

All

Ages

18+ years old

Volunteers

No Healthy Volunteers

Inclusion criteria

Aged ≥18 years
Stable clinical condition for >3 weeks (e.g., no exacerbations)
Resting SpO₂ ≥88% and exercise-induced hypoxemia defined as a drop in SpO₂ of ≥4% and/or a level below 90% during the 6MWT
Informed consent documented by signature

Exclusion criteria

Severe daytime resting hypoxemia (SpO₂ <88%)
Long-term oxygen therapy
Unstable clinical condition requiring adjustment of pharmacological or other treatment modalities, need for intensive care, or presence of relevant severe comorbidities
Inability to comply with study procedures (e.g., due to language barriers, psychological disorders, neurological or orthopedic impairments, walking disability, or inability to ride a bicycle)
Women who are pregnant or breastfeeding
Enrolment in another clinical trial involving active treatment

Trial design

Primary purpose

Treatment

Allocation

Randomized

Interventional model

Sequential Assignment

Masking

Quadruple Blind

52 participants in 3 patient groups

Normoxia

Sham Comparator group

Description:

Sham air (ambient air) (5l/min) will be applied with the oxygen concentrator EverFlo TM via nasal cannula

Treatment:

Other: ambiant air

Hyperoxia

Active Comparator group

Description:

Standardized supplemental oxygen therapy (SSOT) at 5 L/min will be delivered using the EverFlo™ oxygen concentrator via nasal cannula during training.

Treatment:

Other: Oxygen

Hypoxia

Experimental group

Description:

This group will train at moderate altitude

Treatment:

Other: ambiant air