Effect of Remimazolam on Motor Evoked Potential

Korea University

Status: Completed

Conditions: Spine Disease

Treatments: Drug: Remimazolam Besylate; Drug: Propofol

Study type: Interventional

Funder types: Other

Identifiers

NCT05453955

2022GR0051

Details and patient eligibility

About

This study was planned to investigate the degree of effect of remimazolam on MEP compared to propofol when monitoring the motion-inducing potential (MEP).

Enrollment: 20 patients

Sex: All

Ages: 20 to 70 years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• Aged 20-70
• Scheduled for elective spine surgery requiring monitoring of evoked potential
• ASA physical status 1-3

Exclusion criteria

• BMI ≥ 40
• Uncontrolled DM (HbA1c ≥ 9%)
• Contraindications to the study drug: known allergy or hypersensitivity
• Use of rate responsive cardiac pacemaker with bioelectrical impedence
• Diagnosed neuromuscular disorder
• Pre-existing motor weakness

Trial design

Primary purpose: Other

Allocation: Randomized

Interventional model: Crossover Assignment

Masking: Double Blind

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20 participants in 2 patient groups

Propofol-Remimazolam

Experimental group

Description:

General anesthesia was induced and maintained with propofol, then switched to remimazolam after 60 minutes from incision.

Treatment:

Drug: Propofol

Drug: Remimazolam Besylate

Remimazolam-Propofol

Experimental group

Description:

General anesthesia was induced and maintained with remimazolam, then changed to propofol after 60 minutes from incision.

Treatment:

Drug: Propofol

Drug: Remimazolam Besylate