Effect of Remimazolam on the Recovery Quality After Day Surgery

Air Force Military Medical University of People's Liberation Army

Status: Completed

Conditions: Ambulatory Surgery; Elderly Patients

Treatments: Drug: Remimazolam besylate; Drug: etomidate

Study type: Interventional

Funder types: Other

Identifiers

NCT05748665

KY20222277-F-1

Details and patient eligibility

About

The goal of this clinical trial is to compare remimazolam and etomidate in inducing quality of recovery after day surgery for laryngeal mask general anesthesia in elderly patients. The main question it aims to answer is:

• The quality of postoperative recovery induced by remimazolam for laryngeal mask general anesthesia in elderly patients undergoing day surgery is not inferior to that induced by etomidate Participants will be given remimazolam to induce anesthesia。 Researchers will compare etomidate to see if the quality of postoperative recovery.

Enrollment: 118 patients

Sex: All

Ages: 60+ years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• undergoing day surgery under laryngeal mask anesthesia
• American society of anesthesiologists (ASA) grade 1-3
• BMI<30kg/m2

Exclusion criteria

• have benzodiazepines drugs in the latest month cognitive dysfunction
• Cognitive dysfunction and neuropsychiatric disorders
• It was estimated as a difficult airway
• There was a history of adrenal insufficiency, porphyria, or chronic corticosteroid therapy
• There is a contraindication or allergy to benzodiazepines, opioids, etomidate and its components

Trial design

Primary purpose: Treatment

Allocation: Randomized

Interventional model: Parallel Assignment

Masking: Quadruple Blind

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118 participants in 2 patient groups

remimazolam

Experimental group

Description:

remimazolam induction

Treatment:

Drug: Remimazolam besylate

etomidate

Active Comparator group

Description:

etomidate induction

Treatment:

Drug: etomidate