Effect of Remote Ischemic Postcondioning on Glymphatic System in Acute Stroke

Xuzhou Medical University

Status: Unknown

Conditions: Stroke

Treatments: Procedure: remote ischemic postcondioning; Drug: standard therapy

Study type: Interventional

Funder types: Other

Identifiers

NCT05305625

XYFY2022-KL026

Details and patient eligibility

About

Investigators aimed to investigate the changes of glymphatic function after remote ischemic postcondioning treatment in acute ischemic stroke .

Enrollment: 60 estimated patients

Sex: All

Ages: 18 to 80 years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• The patient was 18-80 years old;
• The NIHSS score was ≤ 25 and NIHSS > 5，Glasgow coma score ≥ 8;
• The patients were diagnosed as anterior circulation cerebral infarction and could start remote ischemic postcondioning within 24 hours after onset
• Normal to random time within 24 hours
• Written informed consent signed by patients or their families

Exclusion criteria

• patients receiving thrombolysis or endovascular therapy;
• modified Rankin scale (mRS) score ≥ 2 before this attack;
• other intracranial lesions, such as cerebral hemorrhage, cerebral venous disease, severe subclavian artery stenosis and other diseases involving the brain;
• Arterial blood pressure ≤ 90/60mmHg or ≥ 180/100mmHg after treatment.

Trial design

Primary purpose: Treatment

Allocation: Randomized

Interventional model: Parallel Assignment

Masking: Single Blind

---

60 participants in 2 patient groups

standard therapy

Experimental group

Description:

Patients will be treated with Guideline standard

Treatment:

Drug: standard therapy

remote ischemic postcondioning and standard therapy

Experimental group

Description:

Patients will be treated with remote ischemic postcondioning and Guideline standard , remote ischemic postcondioning twice a day for a total of 3 days.

Treatment:

Procedure: remote ischemic postcondioning

Drug: standard therapy