Effect of Remote Ischemic Preconditioning on Acute Kidney Injury in Patients Undergoing Heart Valve Replacement Surgery With Cardiopulmonary Bypass

Yonsei University

Status: Completed

Conditions: Heart Valve Disease

Treatments: Procedure: Automated cuff-inflator

Study type: Interventional

Funder types: Other

Identifiers

NCT01023152

4-2008-0423

Details and patient eligibility

About

The purpose of this study is to study the effect of remote ischemic preconditioning on acute kidney injury in patients undergoing heart valve replacement surgery with cardiopulmonary bypass.

Full description

Hypothesis : RIPC using tourniquet might be a simple technique with the benefit to provide renal protection without disturbing operating procedure and prolongation of total operating time.

Enrollment: 74 patients

Sex: All

Ages: 18 to 65 years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• patients undergoing complex valve surgery.

Exclusion criteria

• older than 80 years
• those with left main disease >50%, or hepatic or pulmonary disease
• active infective endocarditis
• left ventricular ejection fraction <30%
• myocardial infarction (MI) within 3 weeks
• pre-existing renal dysfunction (serum creatinine (Cr) level >1.4 mg/dl), and those with peripheral vascular disease affecting the lower limbs.

Trial design

74 participants in 1 patient group

Automated cuff-inflator

Experimental group

Treatment:

Procedure: Automated cuff-inflator