Effect of Remote Ischemic Preconditioning on Cardiac Function After Cardiac Surgery

Patrick Meybohm

Status and phase: Withdrawn; Phase 1

Conditions: Atrial Fibrillation; Ventricular Arrythmias; Cardiac Function; Myocardial Injury

Treatments: Procedure: Control/sham procedure; Procedure: Remote Ischemic Preconditioning

Study type: Interventional

Funder types: Other

Identifiers

NCT00882622

A165/08_2

Details and patient eligibility

About

The purpose of this study is to evaluate the effects of Remote Ischemic Preconditioning on cardiac function in patients undergoing cardiac surgery compared to control intervention.

Full description

In detail, we will focus on new onset of atrial fibrillation, ventricular arrhythmias, myocardial injury, and cardiac function. Furthermore, we aim to investigate underlying pathways of RIPC in modifying the perioperative stress response.

Sex: All

Ages: 18+ years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• Patient undergoing heart surgery on cardiopulmonary bypass

Exclusion criteria

• Emergency cases
• Myocardial infarction up to 7 days prior to enrollment
• Ejection fraction less than 30%
• Inability to give informed consent

Trial design

Primary purpose: Treatment

Allocation: Randomized

Interventional model: Parallel Assignment

Masking: Triple Blind

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0 participants in 2 patient groups

RIPC

Active Comparator group

Treatment:

Procedure: Remote Ischemic Preconditioning

CONTROL

Sham Comparator group

Treatment:

Procedure: Control/sham procedure