Effect of Remote Ischemic Preconditioning on Lung Injury After Pulmonary Resection

Cai Li

Status

Completed

Conditions

Lung Neoplasms

Treatments

Procedure: remote ischemic preconditioning

Study type

Interventional

Funder types

Other

Identifiers

NCT01307085

RIP1126

Details and patient eligibility

About

The purpose of this study is to determine whether ischemic preconditioning reduces lung injury in patients undergoing pulmonary resection.

Full description

Remote ischemic preconditioning is an intervention in which brief ischemia of one tissue or organ protects remote organs from a sustained episode of ischemia. It is known that one-lung ventilation in patients undergoing pulmonary resection, which may cause acute lung injury. The investigators did a single-blinded randomised controlled study to establish whether remote ischemic preconditioning reduces lung injury in these patients.

Enrollment

108 patients

Sex

All

Ages

18 to 65 years old

Volunteers

No Healthy Volunteers

Inclusion criteria

Clinical diagnosis of pulmonary carcinoma
Must be received pulmonary lobectomy

Exclusion criteria

Cardiac disease categorized as NYHA classes II-IV
Preoperative severe impairment of respiratory function (arterial oxygen tension (PaO2) <60 mmHg or FEV1<50% predicted),
Pre-existing coagulopathy or thrombocytopenia
Prior receipt of chemotherapy or radiation therapy or immunotherapy
Systemic or local active infections (either clinically defined or suggested by evidence such as elevated C-reactive protein levels, leukocytosis, or a body temperature>38℃)
Peripheral vascular disease affecting the upper limbs
Administration of vitamins, nonsteroidal anti-inflammatory agent or corticosteroid within 3 months.