Effect of Repeated Administration of Liraglutide on Insulinogenic Indices

University of Tartu

Status and phase: Completed; Phase 4

Conditions: Healthy

Treatments: Drug: Liraglutide

Study type: Interventional

Funder types: Other

Identifiers

NCT02089256

LI20/1101

Details and patient eligibility

About

The study investigates the effect of glucagon-like peptide receptor 1 agonist, liraglutide, on insulin secretion. Study hypothesis: the effect of liraglutide on insulin release may change after repeated administration. The effect of liraglutide on insulin release will be tested using graded glucose infusion test (GGIT) in healthy volunteers. GGIT will be performed without medication and repeated 12 hours after first dose of liraglutide and after 3 weeks of treatment with liraglutide.

Enrollment: 10 patients

Sex: All

Ages: 18 to 50 years old

Volunteers: Accepts Healthy Volunteers

Inclusion criteria

• Weight 50-100 kg

Exclusion criteria

• Chronic disease
• Concomitant drug use
• Pregnancy or lactation
• Fasting glucose >6 mmol/L.

Trial design

Primary purpose: Treatment

Allocation: N/A

Interventional model: Single Group Assignment

Masking: None (Open label)

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10 participants in 1 patient group

Liraglutide

Experimental group

Description:

Liraglutide 0.6 mg/day subcutaneously.

Treatment:

Drug: Liraglutide