Effect of Repetitive Transcranial Magnetic Stimulation (rTMS) Over the Brain on the Neurotransmitter Binding

Seoul National University

Status: Terminated

Conditions: Stroke; Hemiplegia

Treatments: Device: Sham rTMS; Device: High frequency rTMS; Device: Low frequency rTMS

Study type: Interventional

Funder types: Other

Identifiers

NCT01819675

E-1211-178-001

Details and patient eligibility

About

The purpose of this study is to determine whether repetitive transcranial magnetic stimulation (rTMS) over the brain can modulate the binding of neurotransmitter (GABA in this study) to its receptor using the special PET study.

Full description

Repetitive transcranial magnetic stimulation (rTMS) can modulate the excitability of cortex but exact mechanism is not well determined in human-beings. Changes in some neurotransmitters' status in brain after rTMS have been suggested as a possible mechanism, but role of GABA is not clear.

Twelve healthy people will be recruited. They will receive the rTMS over the primary motor cortex of the dominant hand. Individual subject will receive three sessions of rTMS with wash-out period (more than 3 days) between the rTMS sessions. Three rTMS sessions are high frequency (10Hz), low frequency (1Hz) and sham rTMS. The order of rTMS sessions will be randomly decided. After completing each rTMS session, [18F]flumazenil-PET will be checked.

The purpose of this study is to investigate 1)whether rTMS over the primary motor cortex can modulate the [18F]flumazenil binding potential and 2)whether the modulation of [18F]flumazenil binding potential by rTMS can be different according to the applied frequency of rTMS.

Enrollment: 6 patients

Sex: All

Ages: 18 to 50 years old

Volunteers: Accepts Healthy Volunteers

Inclusion criteria

• Healthy people
• 18-50 yrs old
• Right handedness
• Written informed consent

Exclusion criteria

• Previous medical diseases such as seizure, stroke, diabetes, hypertension.
• Taking any drugs
• Smoker
• Pregnancy
• Contraindication of PET or MRI
• Stroke or any tumor in MRI
• Metals objects in the head or eyes
• Cardiac pacemaker or cochlear implant

Trial design

Primary purpose: Basic Science

Allocation: Randomized

Interventional model: Crossover Assignment

Masking: Triple Blind

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6 participants in 3 patient groups

High frequency (10Hz) rTMS

Experimental group

Description:

\<high frequency rTMS parameters\> Intensity: 120% of resting motor threshold; Location: Motor hotspot in primary motor cortex for the dominant hand; Frequency: 10Hz; Number of total stimuli: 750; Coil orientation: tangential to scalp

Treatment:

Device: High frequency rTMS

Low frequency (1Hz) rTMS

Experimental group

Description:

\<low frequency rTMS parameters\> Intensity: 120% of resting motor threshold; Location: Motor hotspot in primary motor cortex for the dominant hand; Frequency: 1Hz; Number of total stimuli: 1200; Coil orientation: tangential to the scalp

Treatment:

Device: Low frequency rTMS

Sham rTMS

Sham Comparator group

Description:

\<Sham rTMS parameters\> Intensity: 120% of resting motor threshold; Location: Motor hotspot in primary motor cortex for the dominant hand; Frequency: 1Hz; Number of total stimuli: 1200; Coil orientation: perpendicular to scalp

Treatment:

Device: Sham rTMS