Effect of Resistance Training Variable Manipulation in Postmenopausal Breast Cancer Survivors.

Universidade Federal do Triangulo Mineiro

Status: Unknown

Conditions: Breast Cancer Survivors; Postmenopause

Treatments: Other: Control group; Other: Lower-load resistance training (LL); Other: Higher-load resistance training (HL); Other: Higher-volume resistance training (HV)

Study type: Interventional

Funder types: Other

Identifiers

NCT03644329

CAAE: 82691818.0.0000.5154

Details and patient eligibility

About

This study intends to evaluate the impact of resistance training variable manipulation (intensity and volume) on body composition, fatigability and functional capacity in postmenopausal breast cancer survivors.

Full description

The treatment for breast cancer (chemotherapy, radiotherapy and hormone therapy) provokes collateral effects,such as muscle mass and strength losses, increase of fat mass, fatigue and disability and reduced quality of life in postmenopausal breast cancer survivors. The resistance training is assumed as a non-pharmacologic interventions in postmenopausal breast cancer survivors. However, it is unclear whether the manipulation of training variables (intensity and volume) maximize the effects of resistance training on body composition, fatigability and functional capacity in postmenopausal breast cancer survivors.

Enrollment: 80 estimated patients

Sex: Female

Ages: 50+ years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• Postmenopausal breast cancer survivors;
• No supervised or unsupervised exercise at least for six months prior to the study.

Exclusion criteria

• Alcoholics;
• No controlled blood pressure and glucose;
• Presence of myopathies, arthropathies, and neuropathies;
• Presence of muscle, thromboembolic and gastrointestinal disorders, infection diseases.

Trial design

Primary purpose: Supportive Care

Allocation: Randomized

Interventional model: Parallel Assignment

Masking: None (Open label)

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80 participants in 4 patient groups

Control group, CT

Other group

Description:

In the CT, the postmenopausal breast cancer survivers does not perform exercise.

Treatment:

Other: Control group

Lower-load resistance training (LL)

Experimental group

Description:

In the LL, the postmenopausal breast cancer survivers will be submitted to 12 weeks of resistance training with low loads ( i.e. three sets with 30% of one-repetition maximum).

Treatment:

Other: Lower-load resistance training (LL)

Higher-load resistance training (HL)

Experimental group

Description:

In the HL, the postmenopausal breast cancer survivers will be submitted to 12 weeks of resistance training with high loads (i.e. three sets with 80% of one maximum repetition).

Treatment:

Other: Higher-load resistance training (HL)

Higher-volume resistance training (HV)

Experimental group

Description:

In the HV, the postmenopause breast cancer survivers will be submitted to 12 weeks of resistance training with high volume ( i.e. six sets with 80% one maximum repetition).

Treatment:

Other: Higher-volume resistance training (HV)