Effect of Rocuronium on the Acute Hypoxic Ventilatory Response in Patients With Obstructive Sleep Apnea

Malin Jonsson Fagerlund

Status: Completed

Conditions: Rocuronium; OSA; CPAP; Neuromuscular Blockade; Hypoxic Ventilatory Response

Treatments: Drug: Rocuronium

Study type: Interventional

Funder types: Other

Identifiers

NCT01672606

OSA ROC

Details and patient eligibility

About

This study describe the effect of partial neuromuscular blockade of rocuronium on the acute hypoxic ventilatory response in patients with OSA before and after 3 month of CPAP treatment.

Enrollment: 11 patients

Sex: Male

Ages: 18 to 70 years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• Male with diagnosed moderate OSA (AHI 15-30), untreated, but planned for CPAP treatment. Healthy except for OSA and well controlled tablet treated hypertension where the treatment has not been changed during the last 3 month. None smokers. 18-70 years old. BMI <35.

Exclusion criteria

• If they don´t fit the inclusion criteria

Trial design

Primary purpose: Supportive Care

Allocation: N/A

Interventional model: Single Group Assignment

Masking: None (Open label)

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11 participants in 1 patient group

Rocuronium

Experimental group

Description:

Intravenous infusion of rocuronium with the goal of TOF 0.70 and \>0.90

Treatment:

Drug: Rocuronium