Effect of SAMe Treatment on Recurrence After Radical Treatment of Primary Hepatic Carcinoma

Beijing Insight Science & Technology

Status: Unknown

Conditions: Primary Liver Cancer

Treatments: Drug: S-Adenosyl Methionine

Study type: Interventional

Funder types: Other

Identifiers

NCT03178929

INW161116SAMe

Details and patient eligibility

About

The aim of this study is to explore the effect of SAMe on recurrence after radical treatment of Primary liver cancer.

Full description

Primary liver cancer is now a major health problem. In the worldwide, PLC is the fifth most common cancer in male, the seventh in female, and has the second highest rate to cause death for men . Although the recent advances in treatment of Primary liver cancer have significantly improved the prognosis of patients with Primary liver cancer, the overall survival rate is still unsatisfactory. One of the reasons for the poor prognosis of Primary liver cancer is its high rate of recurrence. Anti-relapse treatment remains a pressing work to do.

In recent years, some study reported that SAMe had an impact on promoting apoptosis and inhibiting the growth on breast cancer, colon cancer, gastric cancer and liver cancer in vitro and vivo.

In this study, we aim to examine whether SAMe have an effect on improving patients' recurrence after radical treatment of Primary liver cancer.

Enrollment: 207 estimated patients

Sex: All

Ages: 18+ years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• Patient must sign the informed consent prior to the beginning of any study-related procedures;
• Patients diagnosed of Primary liver cancer;
• BCLC Stage：Stage 0、Stage A;
• Accept radical treatment;

Exclusion criteria

• With any other anti-cancer treatment before or after the surgery;
• Patients with extrahepatic metastasis;
• Patients with apparent cardiac, pulmonary, cerebral and renal dysfunction;
• Subjects accepting other trial drugs or participating in other clinical trials;
• Female with pregnancy or during the lactation period.

Trial design

Primary purpose: Prevention

Allocation: Randomized

Interventional model: Parallel Assignment

Masking: None (Open label)

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207 participants in 2 patient groups

S-Adenosyl Methionine Treatment

Experimental group

Description:

Patients will be treated with S-Adenosyl Methionine treatment after radical treatment. 2000mg, po

Treatment:

Drug: S-Adenosyl Methionine

control group

No Intervention group

Description:

Patients will be treated without S-Adenosyl Methionine treatment after radical treatment.