Effect of Sedatives on Perioperative Electroencephalogram in Elderly Patients Undergoing Spinal Anesthesia

Seoul National University

Status: Unknown

Conditions: Effect of Sedatives

Treatments: Device: Electroencephalogram

Study type: Observational

Funder types: Other

Identifiers

NCT04248075

20200120

Details and patient eligibility

About

In the present study, we observe perioperative findings of electroencephalogram in sedated and non-sedated elderly patients undergoing total knee arthroplasty under spinal anesthesia.

Full description

In the present study, we observe perioperative findings of electroencephalogram in sedated and non-sedated elderly patients undergoing total knee arthroplasty under spinal anesthesia. Electroencephalogram is performed before, during, and 1 day after surgery.

After the induction of anesthesia, sedation is performed according to the patient's request. If a patient want to be sedated during surgery, one of the three sedatives (dexmedetomidine, propofol, and midazolam) is administered.

Enrollment: 120 estimated patients

Sex: All

Ages: 65+ years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• Eldery patients scheduled for spinal anesthesia

Exclusion criteria

• MMSE ≤ 23
• Hemodynamic unstability
• Liver disease
• Renal disease

Trial design

120 participants in 4 patient groups

Control

Description:

Patients who do not want to be sedated during spinal anesthesia are included. Electroencephalogram is performed before, during, and 1 day after surgery.

Treatment:

Device: Electroencephalogram

Dexmedetomidine

Description:

Patients who want to be sedated during spinal anesthesia are included. Electroencephalogram is performed before, during, and 1 day after surgery. After the induction of spinal anestheisa, dexmedetomidine is administered for sedation during surgery.

Treatment:

Device: Electroencephalogram

Propofol

Description:

Patients who want to be sedated during spinal anesthesia are included. Electroencephalogram is performed before, during, and 1 day after surgery. After the induction of spinal anestheisa, propofol is administered for sedation during surgery.

Treatment:

Device: Electroencephalogram

Midazolam

Description:

Patients who want to be sedated during spinal anesthesia are included. Electroencephalogram is performed before, during, and 1 day after surgery. After the induction of spinal anestheisa, midazolam is administered for sedation during surgery.

Treatment:

Device: Electroencephalogram