Effect of Selenium Supplementation on Trace Mineral Antioxidant Enzyme and Amino Acid Metabolism in Infants

Abbott

Status: Completed

Conditions: Preterm Infants

Treatments: Other: selenium and sodium selenite supplementation; Other: Without selenium and sodium selenate supplementation; Other: selenium and sodium selenate supplementation; Other: Without selenium and sodium selenite supplementation

Study type: Interventional

Funder types: Industry

Identifiers

NCT02066610

AD61

Details and patient eligibility

About

The objectives of the study were to assess the serum selenium, zinc, and copper status and plasma and white blood cell antioxidant enzyme activities of low birth weight infants receiving selenium supplemented and non-selenium supplemented parenteral nutrition from initiation of parenteral nutrition until discontinuation of preterm formula or hospital discharge.

Enrollment: 47 patients

Sex: All

Volunteers: No Healthy Volunteers

Inclusion criteria

• Weight less than 1500 g at birth
• Not capable of receiving enteral feedings prior to 7 days postnatally

Exclusion criteria

• Metabolic abnormalities such as inborn errors of metabolism
• Current viral infections
• Enterocolitis confirmed by diagnosis
• Presence of congenital anomalies, severe cardiac disease, liver disease, severe renal and neurological diseases, cholestasis, hemolytic disease and severe gastrointestinal disease
• Evidence of chronic white blood cell disease

Trial design

47 participants in 4 patient groups

PN selenium and formula sodium selenate

Experimental group

Description:

Parenteral nutrition (PN) with selenium and sodium selenate supplementation of infant formula

Treatment:

Other: selenium and sodium selenate supplementation

PN selenium and formula sodium selenite

Experimental group

Description:

Parenteral nutrition (PN) with selenium and sodium selenite supplementation of infant formula

Treatment:

Other: selenium and sodium selenite supplementation

PN without selenium and formula sodium selenate

Experimental group

Description:

Parenteral nutrition (PN) without selenium and sodium selenate supplementation of infant formula

Treatment:

Other: Without selenium and sodium selenate supplementation

PN without selenium and formula sodium selenite

Experimental group

Description:

Parenteral nutrition (PN) without selenium and sodium selenite supplementation of infant formula

Treatment:

Other: Without selenium and sodium selenite supplementation