Effect of Self Assembling Peptide on White Spot Lesion (regeneration)

Raneen Ahmed

Status and phase: Unknown; Early Phase 1

Conditions: White Spot Lesion of Tooth

Treatments: Drug: remineralizing agent; Drug: Self Assembling peptide

Study type: Interventional

Funder types: Other

Identifiers

NCT03930927

1998

Details and patient eligibility

About

During re-mineralization of white spot lesion, Will biomimetic self-assembling peptides improve the re-mineralizating effect of the post orthodontic white spot lesion compared to fluoride-based delivery systems?

Full description

Conservative dentistry no longer prefers the "drill and fill" concept and advocates reversal of lesions via remineralization. . Remineralization is the process of restoring minerals - again, in the form of mineral ions - to the hydroxyapatite latticework structure. It is three-dimensional, and the lost ions must be replaced with ions having the exact same shape, size and the same electrical charge as those lost from the lattice.

Fluoride and self-assembling peptides have been used as adjuncts to enhance remineralization.

Enrollment: 32 estimated patients

Sex: All

Ages: 12 to 22 years old

Volunteers: Accepts Healthy Volunteers

Inclusion criteria

• Patients with post orthodontic white spot lesion.
• Patients with good oral hygiene.
• Patients with good general health.
• Cooperative patients.
• Subjects who signed the informed consent.

Exclusion criteria

• Patients with tetracycline pigmentation and dental fluorosis.
• Enamel cavitation.
• Disable patient.
• patient with any systemic disease or severe medical complications.

Trial design

Primary purpose: Treatment

Allocation: Randomized

Interventional model: Parallel Assignment

Masking: Single Blind

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32 participants in 2 patient groups

Self Assembling peptide

Experimental group

Description:

intervention

Treatment:

Drug: Self Assembling peptide

Drug: remineralizing agent

Fluoride

Experimental group

Description:

Comparator

Treatment:

Drug: Self Assembling peptide

Drug: remineralizing agent