Effect of Sevoflurane on the Onset Characteristics and Intubating Conditions of Rocuronium (SRI)

Maharashtra University of Health Sciences

Status and phase: Completed; Phase 4

Conditions: Muscle Relaxation Caused by Sevoflurane

Treatments: Drug: Rocuronium; Drug: Sevoflurane

Study type: Interventional

Funder types: Other

Identifiers

NCT02785653

PR/ANAES/C/61

Details and patient eligibility

About

This study evaluates the potentiation of muscle relaxation caused by rocuronium by inhalational agent sevoflurane. Half the patients will be ventilated with oxygen ,nitrous oxide and sevoflurane during induction of anaesthesia and half will be ventilated only with oxygen and nitrous oxide.

Full description

Rocuronium is a non depolarizing muscle relaxant. Inhalational general anaesthetic agents like Sevoflurane have some muscle relaxation effect by depressing the spinal motor neurons. Inhalational anaesthetics also alter the tonic input received from descending modulatory systems from the brain. Deep anaesthesia with inhalational agents may cause some degree of neuromuscular blockade.

Enrollment: 60 patients

Sex: All

Ages: 18 to 65 years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• American society of anaesthesiologists physical status 1 and 2
• Age between 18-65
• Mallampatti classification 1 and 2

Exclusion criteria

• Patients refusal to participate
• American society of anaesthesiologists physical status 3 and 4
• Mallampatti classification 3 and 4
• Patients with neuromuscular disorder
• Patients on medications that affect neuromuscular block
• Pregnant and lactating patients

Trial design

Primary purpose: Treatment

Allocation: Randomized

Interventional model: Parallel Assignment

Masking: None (Open label)

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60 participants in 2 patient groups

sevoflurane and rocuronium

Experimental group

Description:

After induction of general anaesthesia, patients in the sevoflurane group were ventilated with fresh gas flow of 5 lites per minute consisting of 66.6% nitrous oxide and 33.3% oxygen with 2% inspired concentration of sevoflurane. After stabilization of end tidal carbondioxide to 30-35 mmHg ,intravenous rocuronium 0.6mg per Kg body weight was injected

Treatment:

Drug: Sevoflurane

Drug: Rocuronium

rocuronium

Active Comparator group

Description:

After induction of general anaesthesia, patients in the control group were ventilated with fresh gas flow of 5 lites per minute consisting of 66.6% nitrous oxide and 33.3% oxygen . After stabilization of end tidal carbondioxide to 30-35 mmHg ,intravenous rocuronium 0.6mg per Kg body weight was injected

Treatment:

Drug: Rocuronium