Effect of Sevoflurane vs Desflurane on Mechanical Power in Laparoscopic Cholecystectomy (VAPOR)

Konya City Hospital

Status: Not yet enrolling

Conditions: Perioperative Respiratory Mechanics

Treatments: Drug: Sevoflurane; Drug: Desflurane

Study type: Interventional

Funder types: Other

Identifiers

NCT07295158

LC-MP-2025-01"

Details and patient eligibility

About

This single-center, prospective, randomized, assessor-blinded clinical trial aims to compare the effects of sevoflurane and desflurane anesthesia on intraoperative mechanical power in adult patients undergoing elective laparoscopic cholecystectomy. Mechanical power will be measured at three standardized time points using a validated formula, and secondary outcomes include driving pressure values and early postoperative respiratory complications (desaturation, laryngospasm, bronchospasm, cough).

Enrollment: 138 estimated patients

Sex: All

Ages: 18 to 65 years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• Adults aged 18-65 years

ASA Physical Status I-II

Scheduled for elective laparoscopic cholecystectomy

Able to provide written informed consent

Exclusion criteria

Known hypersensitivity or contraindication to study medications (sevoflurane or desflurane)

Severe chronic obstructive pulmonary disease (COPD)

Uncontrolled bronchial asthma

Decompensated heart failure (NYHA Class III-IV)

History of prior lung surgery

Morbid obesity (BMI > 35 kg/m²)

Pregnancy

Refusal to participate or inability to provide informed consent

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Trial design

Primary purpose: Prevention

Allocation: Randomized

Interventional model: Parallel Assignment

Masking: Single Blind

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138 participants in 2 patient groups

Arm S- Sevoflurane Group

Experimental group

Description:

Maintenance of general anesthesia with sevoflurane 2% during laparoscopic cholecystectomy. Mechanical power is measured at three intraoperative time points using standardized ventilator settings.

Treatment:

Drug: Sevoflurane

Arm D-desflurane group

Experimental group

Description:

Maintenance of general anesthesia with desflurane 6% during laparoscopic cholecystectomy. Mechanical power is measured at three standardized intraoperative time points under identical ventilator settings.

Treatment:

Drug: Desflurane