Effect of Short-term Chinese Tea-flavor Liquor Consumption (ESTCTFLC)

Zhejiang University

Status and phase: Completed; Phase 1

Conditions: Cardiovascular Diseases

Treatments: Dietary Supplement: Guizhou Meijiao Liquor; Dietary Supplement: Tea-flavor Liquor

Study type: Interventional

Funder types: Other

Identifiers

NCT01294995

ST Chinese liquor study

Details and patient eligibility

About

Human studies of Chinese liquor are sparse. The investigators hypothesize that short-term Chinese Tea-flavor liquor (TFL) consumption may be beneficial to inflammation biomarkers and CVD risk factors. Guizhou Meijiao Liquor (GML) is a traditional Chinese liquor, fermented from sorghum, corn, sticky rice, wheat and rice, while TFL is a novel Chinese liquor fermented from above 5 grains plus green tea.

Forty-five volunteers(23 males, 22 females) were selected to participate a paralleled randomized trial drinking 30 mL two kinds of Chinese liquors: TFL and GML respectively with meal every day for 28 days. Serums of volunteers were collected for analyzing serum lipids, inflammation biomarkers and CVD risk factors.

TFL could significantly decrease systolic blood pressure of males, but increase diastolic blood pressure of females. TFL could also decreased blood lipid of volunteers, especially for females. Both liquor significantly decrease serum uric acid and glucose in males and females. The effect of the two liquors on inflammation biomarkers were complicated and needs further research work.

TFL may possess more beneficial effect on CVD risk factors than GML probably because of the special fermentation products of green tea with other grains.

Enrollment: 45 estimated patients

Sex: All

Ages: 23 to 28 years old

Volunteers: Accepts Healthy Volunteers

Inclusion criteria

• Healthy male and female volunteers

Exclusion criteria

• Subjects with a history of liver disease, diabetes, or heart disease
• Smokers

Trial design

Primary purpose: Treatment

Allocation: Randomized

Interventional model: Parallel Assignment

Masking: None (Open label)

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45 participants in 2 patient groups, including a placebo group

Tea-flavor Liquor, taken with meal

Experimental group

Description:

including 12 males and 11 females

Treatment:

Dietary Supplement: Tea-flavor Liquor

Guizhou Meijiao Liquor, taken with meal

Placebo Comparator group

Description:

including 11 males and 11 females

Treatment:

Dietary Supplement: Guizhou Meijiao Liquor