Effect of Short-term Oxygen During CPET in COPD

University of Zurich (UZH)

Status and phase: Completed; Phase 2

Conditions: Chronic Obstructive Pulmonary Disease

Treatments: Procedure: Oxygen application

Study type: Interventional

Funder types: Other

Identifiers

NCT03196089

KEK-ZH-NR. 2012-0251_2

Details and patient eligibility

About

In a randomized, sham-controlled trial the investigators will test whether supplemental oxygen given during cardiopulmonary exercise testing will improve exercise performance and physiological parameters in patients with chronic obstructive pulmonary disease.

Enrollment: 20 patients

Sex: All

Ages: 20 to 80 years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• diagnosis of chronic obstructive pulmonary disease
• on optimized medical therapy and in stable condition for at least 4 week
• desaturate in the 6 minute walking test by at least 4% to values <92%

Exclusion criteria

• unstable conditions
• pregnant women
• patients with relevant concomitant lung disease and severe daytime hypoxemia

Trial design

Primary purpose: Supportive Care

Allocation: Randomized

Interventional model: Crossover Assignment

Masking: Triple Blind

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20 participants in 2 patient groups

Supplemental oxygen

Experimental group

Description:

Supplemental oxygen will be applied via a mask during CPET

Treatment:

Procedure: Oxygen application

Sham room air

Sham Comparator group

Description:

Room air will be applied similarly to oxygen

Treatment:

Procedure: Oxygen application